ABSTRACT
60 patients with pathologically diagnosed erosive lichen planus of bilateral buccal mucosa were included.The lesion on one side was treated by local application of triamcinolone acetonide dental paste(test group),the lesion on the other side without treatment was used in the control group.7,1 4,21 and 28 d after treatment the pain level and the lesion situation scores in the test group decreased significantly (P <0.001 ),and lower than those in the control group at the same time point(P <0.05).No adverse reaction was found in the 2 groups. Triamcinolone Acetonide Dental Paste is effective in the treatment of erosive oral lichen planus.
ABSTRACT
<p><b>OBJECTIVE</b>The aim of the study was to evaluate the clinical efficacy of Oratest in detecting oral mucosal lesions.</p><p><b>METHODS</b>Sixty patients with oral mucosal lesions that were suspected as carcinoma or premalignant lesions were divided into two groups randomly. The lesions were stained with Oratest by topical application in one group and rinse application in another group. Staining results were recorded and compared with the pathological diagnosis.</p><p><b>RESULTS</b>The sensitivity of Oratest stain to oral carcinoma and dysplasia were 93.9% and 42.9%, respectively. The difference between rinse application and local application showed no significance(P > 0.01).</p><p><b>CONCLUSION</b>Oratest can be used as a method of diagnosing squamous cell carcinoma of oral mucosa, but its reliability in screening oral pre-malignant lesions is still uncertain.</p>
Subject(s)
Adolescent , Adult , Aged , Child , Female , Humans , Male , Carcinoma, Squamous Cell , Diagnosis , Coloring Agents , Leukoplakia, Oral , Diagnosis , Mouth Mucosa , Pathology , Mouth Neoplasms , Diagnosis , Precancerous Conditions , Diagnosis , Staining and Labeling , Tolonium ChlorideABSTRACT
Objective:To establish an animal model of oral lichen planus (OLP). Methods:Human non-erosive OLP lesion tissue was surgically transplanted into dorsal hypoderm or tongue abdomen in 10 severe combined immunodeficiency (SCID) mice, thereafter, growth and possible alterations of histopathological characteristics of the xenografts were observed for 2 weeks. Results:All the xenografts transplanted into dorsal hypoderm or tongue abdomen healed well.Partial liquefaction and subepithelial lymphocytes diffuse infiltration were observed in epithelial basement membrane in the first week after transplantation. During the subsequent week, the degenerated moiety was hardly to be seen, and the number of subepithelial lymphocytes was gradually decreased. Conclusions:The epithelia of OLP xenografts grow well in SCID mice but can not keep its histopathological features.
ABSTRACT
Objective: To detect methylation status of p16 CDKN2A exon 1 during experimental carcinogenesis in rats. Methods:Thirty male clean SD rats were fed with 0.02 g/L of 4-nitroquinoline-oxide (4NQO) in drinking water.13, 16 and 24 weeks after experiment the normal, moderate-severe dysplasia and invasive squamous cell carcinoma tissues were removed from their tongues respectively; then the methylation status of p16 CDKN2A exon 1 were detected by methylation-specific PCR(MSP). Results:A 123 bp-unmethylated product was amplified in all samples but the methylated product was not detected in any of the samples. Conclusion: The p16 CDKN2A exon 1 appeares to be unmethylated during carcinogenesis of tongue cancer in experimental rats.